Two people were taken to the University of Chicago Medical Center.
Two people were injured in a crash Friday on the Dan Ryan Expressway.
About 12:21 a.m., three vehicles and a motorcycle were involved in a collision on the outbound local lanes near 63rd street, Illinois State Police said.
A male was taken to the University of Chicago Medical Center in serious condition, state police said. A female was taken to the same hospital with minor injuries.
Outbound local lanes are closed at the scene as police investigate the crash.
No further information was immediately available.